Organ specific and systemic autoimmune diseases

2019-12-15 13:03

Organspecific and systemic autoimmune diseases. Organspecific diseases include diseases such as Hashimoto's thyroiditis and coeliac disease, in which specific organs (in coeliac disease, the lining of the small intestine) are attacked by the immune system. Systemic diseases can affect any part of the body and several systems at once,Transplantation of a stemcellenriched population from (NZW x BXSB)F1 mice into normal mice also induced autoimmune disease in the recipients. These results indicate that both systemic autoimmune disease and organspecific autoimmune disease originate from defects that reside within the stem cells; the thymus and environmental factors such as sex hormones appear to act only as accelerating factors. organ specific and systemic autoimmune diseases

Proc. Natl. Acad. Sci. USA87(1990) in the expression of either organspecific autoimmunities directed toward specific hematological cells or systemic autoimmune injuries resulting from immune Inaddition, thesefindings suggest that genetically based susceptibility to most classes of au toimmunediseases, at least in mice, reside within the hem

Autoimmune mechanisms underline many diseases, some organspecific, others systemic in distribution. Autoimmune disorders can overlap: an individual may have more than one organspecific disorder; or more than one systemic disease. Genetic factors such as HLA type are important in autoimmune disease, and it is MG is an organspecific autoimmune disease, with antibodies directed against the acetylcholine receptor. These antibodies compete with acetylcholine released by the nerve terminal, interfering with neuromuscular transmission (Fig. 1). Thymic hyperplasia occurs inorgan specific and systemic autoimmune diseases OrganSpecific Autoimmune Diseases: In organspecific autoimmune diseases, the autoimmune responses are directed against antigens present only in a particular organ (Table 20. 2). i. In some autoimmune diseases the autoantibodies bind to selfantigens in the organ

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In systemic diseases the immune system attacks self Other articles where Organspecific autoimmune disease is discussed: autoimmunity: An organspecific disease is one in which an immune response is directed toward antigens in a single organ. organ specific and systemic autoimmune diseases

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